AB0339 PREVALENCE AND ASSOCIATED FACTORS OF LOW BONE MINERAL DENSITY IN ADULTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Background: Patients with Systemic Lupus Erythematosus (SLE) are at risk of osteoporosis (OP) and fragility fractures (FFx) because the disease or its treatments. We assessed prevalence factors for OP in patients SLE. Objectives: Our objective is to determine bone mineral density (BMD) loss fracture SLE undergoing dual-energy X-ray absorptiometry (DXA). Methods: This a cross sectional study conducted during year 2020 Rheumatology internal medicine departements Taher Sfar hospital Mahdia, Tunisia. included aged ≥18 years diagnosis according 1997 ACR 2012 SLICC criteria. renal hepatic osteodystrophy, receiving bisphosphonates were excluded from study. The BMD values measured by DXA. T-score, Z-scores lumbar spine (LS) femoral neck (FN) determined. was defined as value T-score less equal -2.5 SD postmenopausal women men more than 50 old, -2 premenopausal old. Results: Forty-six included. mean age 47.19±16.45 [18-85], duration 2.52±3.46 [15days-15years]. SLEDAI score 5.34±4.82. As regards menstrual history female patients: 56.5% premenopausal, 43.5% post-menopausal 6% had premature menopause. 13% our gave smoking. BMI 27.6 ± 6 kg/m2 [15-39.8]. FFx diagnosed 4 (9%) first 45years. GCs used 65.2% cases (30 patients). daily dose 10 mg/day cumulative 20g. Calcium Vitamin D intake mentioned association other rheumatic diseases found 14 patients. FN LS respectively 0.02±1.17 -1.32±1.36. Z-score 0.53±1.14 -0.6±1.26. It that 17 (37% cases) OP, 12 osteopenia (26%) (37%) normal BMD. 37% LS, 23.9% 6.5% 21.7% FN. Low significantly correlated increased (p=0.01) duration(p=0.05),post-menopausal status(p=0.04), higher (p=0.004), musculoskeletal involvement (p=0.01), activity (p=0.05), Erythrocyte sedimentation Rate C-Reactive Protein (p=0.007), low serum complement C3 (p=0.009) C4 (p=0.04) doses (p=0.01). also mostly affected intake, CRP while score, (p<0.001 all cases). Gender, smoking cardiovascular comorbidities no significant impact on Conclusion: common but unrecognised complication frequency both peripheral vertebral FFx. suggests high profile which seems be associated age, duration, status, GCs. References: [1]Dey, M., & Bukhari, M. (2018). Predictors systemic lupus erythematosus. Lupus, 27(9), 1547–1551. Disclosure Interests: None declared